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ATI Radeon X1800 GTO Video Card Review

The Radeon X1800 GTO came to us as a bit of a surprise. It showed up with very little advanced notice and is also seems to have caught Nvidia by surprise also. ATI knew they needed to launch a worthy competitor to the 7600GT and there solution is the Radeon X1800 GTO video card. Nvidia had planned to release the 7600GT against ATI?s X1600 Pro and X1600XT models, which would have been a very ugly affair for the ATI cards. Instead ATI took their R520 core and did a number of modifications to the card to cut back performance and the price tag. With an MSRP of $249, the X1800 GTO is essentially a modified Radeon X1800 XL GPU with fewer pipelines and ROPs. Here, we see a slight decrease from 16 pipelines down to 12 as well as a drop in Raster Operator Units ROPs from 16 to 8. Other than these changes the X1800 GTO retains all the features and functionality of the full Radeon X1800 series of GPUs.

Let?s get straight to the ugly truth, the X1800 GTO is not hard launching today and has no availability until March 31st. Yes, that means that ATI is doing a paper launch to spoil NVIDIAs launch this week. Legit Reviews hates paper launches and ATI knows this, but they love to do them just to get some numbers and press out on the market. ATI is very dedicated to delivering this card to market but a hard launch is the only way to go anymore. When NVIDIA launched their 7600 GT, 7900 GT and 7900 GTX yesterday they were available to be bought right then and there. Since the R520 is not a new core and the GTOs arent shipping yet it makes you wonder who got owned in this round of the video card battle. Only time will tell on that front!

When it comes to pricing and card selection on the $200+ side of the market ATI has a number of solutions out on the market. Actually the X1800 GTO will be the seventh ATI card in the $249 to $549 price range.

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SEE ALSO: Best Buy ends workfromhome programBest Buys February announcement that itd be laying off 400 employees didnt mean the remaining employees were in the clear, as throughout the year, smaller groups of employees have been getting laid off typically on Tuesdays.In fact, according to a Star Tribune report, employees have taken to calling Tuesdays Tornado Tuesdays or Termination Tuesdays.Whenever someone leaves their desk, we think that person just got laid off, when he or she might just be going to the bathroom, one unnamed employee told the Strib.As part of the restructuring taking place in the wake of the disaster that was former CEO Brian Dunns tenure, the company announced plans to cut $700 million in costs. According to the Strib, execs have so far trimmed about $300 million, with that number growing as the company lays off employees in groups ranging from single digits to up to 25.While Termination Tuesdays makes Best Buy a more stressful place to work and certainly doesnt boost employee morale, one of the benefits of laying off employees in small groups is that it allows Best Buy to avoid the negative publicity companies receive when they lay off hundreds of workers at once.Last month, Time, citing Best Buys impressive stock performance this year, proclaimed that the company is back from the dead. Thats good news for investors and execs, but not necessarily for the corporate rankandfile especially on Tuesdays.

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Cancer drug damages mouse hearts

Heart damage from chemotherapy may be due to leaky pipes. Sunitinib, a cancer drug known to harm heart tissue, wipes out cells that seal blood vessels, Vishnu Chintalgattu of the biotech company Amgen and colleagues report May 29 in Science Translational Medicine.

These cells, called pericytes, normally wind around tiny blood vessels, or microvessels, keeping them healthy and plugging leaks like rubber patches glued to bicycle inner tubes.

Researchers examined tissue from drugtreated and untreated mice and noticed that sunitinib stripped pericytes from microvessels in the heart. Without the sheaths of sticky cells, more than twice as much fluid seeped from the microvessels.

Leaking liquid may explain why as many as 28 percent of sunitinibtreated cancer patients end up with heart trouble, the researchers suggest.

But there may be a way to fix the plumbing problem. Thalidomide, the molecule made famous for causing birth defects and now used to treat cancer, can protect pericytes from slaughter by sunitinib, the team reports.

Dosing labgrown pericytes with only sunitinib killed the cells, but giving them both drugs didnt seem to do any harm. And when researchers grafted human cancer tissue into mice and treated them with the two drugs, the animals tumors shrank and their hearts pumped normally.

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bypassing the pluripotent stem cell stage May 2

SuChun Zhang center, professor of neuroscience in the School of Medicine and Public Health, talks with postdoctoral student Lin Yao in his research lab at the Waismam Center.

Photo: Jeff Miller

A UWMadison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervoussystem cells without passing through the doitall stage called the induced pluripotent stem cell, or iPSC. IPSC cells can generate any cell type, which could be a problem for cellbased therapy to repair damage due to disease or injury in the nervous system.

In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy.

A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form. Unlike other viruses used for this process, the Sendai virus does not become part of the cells genes.

Progenitor cells grown from the skin of ALS or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening. . Eventually, the process could produce cells used to treat conditions like spinal cord injury and ALS.

Jianfeng Lu, Zhangs postdoctoral research associate at the UWMadison Waisman Center, removed skin cells from monkeys and people, and exposed them to Sendai virus for 24 hours. Lu then warmed the culture dish to kill the virus without harming the transforming cells. Thirteen days later, Lu was able to harvest a stem cell called an induced neural progenitor. After the progenitor was implanted into newborn mice, neural cells seemed to grow normally, without forming obvious defects or tumors, Zhang says.

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports, had a different goal. Our idea was to turn skin cells to neural progenitors, cells that can produce cells relating to the neural tissue. These progenitors can be propagated in large numbers.

The research overcomes limitations of previous efforts, Zhang says. First, the Sendai virus, a kind of cold virus, is considered safe because it does not enter the cells DNA, and it is killed by heat within 24 hours. This is quite similar to the fever that raises our temperature to remove cold virus. Second, the neural progenitors have a greater ability to grow daughter cells for research or therapy. Third, the progenitor cells are already well along the path toward specialization, and cannot become, say, liver or muscle cells after implantation. Finally, the progenitors can produce many more specialized cells.

The neurons that grew from the progenitor had the markings of neurons found in the rear of the brain, and that specialization can also be helpful. For therapeutic use, it is essential to use specific types of neural progenitors, says Zhang. We need regionspecific and functionspecific neuronal types for specific neurological diseases.

Progenitor cells grown from the skin of ALS Lou Gehrigs disease or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening, Zhang adds.

Eventually, the process could produce cells used to treat conditions like spinal cord injury and ALS..

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called unfit for office

The 70yearold Filner served five terms in Congress before being elected mayor in 2012. Rep. Susan Davis, a San Diegoarea congresswoman who served alongside Filner, joined calls for his resignation on Monday.

Despite his inclusive vision for San Diego, Mayor Filner has lost the confidence of San Diegans to lead, Davis, a fellow Democrat, said in a written statement. He has taken advantage of the trust the voters placed in him and lost both the promise and capacity to ignite positive change. His behavior, if not illegal, is reprehensible.

Davis said she and Filner have never had a smooth relationship, but she respected his passion for our city and his interest to change the way business is done.

But all of that is now lost because he did not have enough passion for the city to curb his incomprehensible and unacceptable behavior, she said.

Another Democrat, former City Councilwoman Donna Frye, and two attorneys who say they represented accusers had leveled allegations against the mayor before Monday.

Jackson said her decision to resign was clinched after Filners deputy chief of staff resigned in June. Filner refused to listen to someone he had known for 35 years, and who told him explicitly, during a senior staff meeting, that his behavior with women was terrible and possibly illegal.

Filner laughed it off, she said. She said Filner challenged her to provide one example of improper behavior; when she brought up his comments about wearing underwear, He had no comeback, she said.

The San Diego Sheriffs Department has established a hotline for accusers, who are allowed to remain anonymous under California law. Since the phone number was announced Friday, the department has received calls, spokeswoman Jan Caldwell told CNN on Monday.

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Rheumatoid Arthritis

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Symptoms of Rheumatoid ArthritisRheumatoid arthritis RA is a chronic longterm disease. Rheumatoid arthritissymptoms can come and go, and each person with RA is affected differently. Some people have long periods of remission. Their rheumatoid arthritis is inactive, and they have few or no symptoms during this time. Other people might have nearconstant rheumatoid arthritis symptoms for months at a stretch.

Although rheumatoid arthritis can involve different parts the body, joints are always affected. When the disease acts up, joints become inflamed. Inflammation is the bodys natural response to infection or other threats, but in rheumatoid arthritis inflammation occurs inappropriately and for unknown reasons.

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Relationship Advice Articles about Romance

Men really are different from women in some important ways. Remember men are from Mars, women are from Venus. If youre in a relationship, you may wonder what men want and you might seek advice on love. Relationships arent easyif only you could use love spells to find a soulmate! To learn what men want, you first need to learn the basics of the male psyche.

Hes actionoriented. Doing is his favorite mode.

Women think differently than men do about relationships. Understanding men and relationships is a lot easier if you can, momentarily, think like a man. Knowing what motivates a guy is the best love advice there isnd the easiest way to find a soulmate!

Ingenio does not refer, recommend, endorse or guarantee any advisor or services. We do not represent or warrant that the advisor you select is qualified or licensed to provide the information or advice you seek. You are solely responsible to select your advisor and determine whether that advisor has the right qualifications and experience for your needs. Ingenio is not responsible for and does not warrant any advice or information that you receive from your advisor. You and the advisor are solely responsible for your conversations and communications. Whether or not you rely on any advice or information given is your decision.